Piperidineacrylate derivatives as potential antiallergy agents
| Autor: | Yumiko Satoh, Fukumi Hiroshi, Toshiaki Sakamoto, Kazuhiro Itoh, Takeshi Yamaguchi, Mitsuo Sugiyama, Yumiko Kamigaki |
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| Rok vydání: | 1993 |
| Předmět: |
Male
Magnetic Resonance Spectroscopy Chemistry Guinea Pigs Passive Cutaneous Anaphylaxis General Chemistry General Medicine Pharmacology Antiallergy Agents Rats Rats Sprague-Dawley Acrylates Piperidines Antiallergic agent Drug Discovery medicine Hypersensitivity Organic chemistry Structure–activity relationship Animals Terfenadine Oxatomide medicine.drug |
| Zdroj: | Chemicalpharmaceutical bulletin. 41(5) |
| ISSN: | 0009-2363 |
| Popis: | A new series of piperidineacrylate derivatives was prepared and evaluated for antiallergic activity. Most of the compounds showed potent activities in the rat passive cutaneous anaphylaxis (PCA) assay. In particular, ethyl 1-[2-bis(4-fluorophenyl)methoxyethyl]-4-piperidimeacrylate (1a) was more potent than oxatomide and terfenadine in this assay, and was selected for further study. Some pharmacological properties of 1a are presented. |
| Databáze: | OpenAIRE |
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