Is biological repair of Heart on the Horizon?
| Autor: | H R Ahmad, Satwat Hashmi |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
business.industry Regeneration (biology) Review Article Stem cells General Medicine 030204 cardiovascular system & hematology medicine.disease Biological repair Cell biology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine medicine.anatomical_structure Smooth muscle Cardiomyocytes and Cardiac regeneration Medicine Heart repair Myocardial infarction Stem cell business Fibroblast Cytokinesis |
| Zdroj: | Pakistan Journal of Medical Sciences |
| ISSN: | 1681-715X |
| DOI: | 10.12669/pjms.334.12938 |
| Popis: | The stem cells keep us young by endogenously repairing us upon need. They do so bysmartly one step forward towards differentiation while another step backward to nurturethe undifferentiated stem cells. They are building blocks for every organ witha differential rate of repair of worn out tissues. Since stem cells can be cultured with a normal karyo type, they could be the ideal source for heart repair after myocardial infarction. As opposed to lower vertebrates and neonatal mice, cardiac regeneration in adult mammalian heart seems to be difficult to assess with a solid evidence of cytokinesis. It becomes more difficult to quantify the level of regeneration after myocardial infarction injury against a background of a large invasion of proliferating inflammatory cells. The question to beraised is how the renewal of a piece of myocardium follows the time line of picking upcell types in series: cardiomyocytes, endothelial cells, smooth muscle cells, fibroblast, pacemaker cells, conducting and Purkinje cells to bring the orchestration of rhythmically contracting and relaxing heart. This review focuses on where we are onthe status of heart repair and cardiac regeneration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|