Evolution of the resistance to antibiotics of bacteria involved in urinary tract infections: A 7-year surveillance study
| Autor: | Antonio Martínez-Brocal, José María Navarro-Marí, José Gutiérrez-Fernández, Antonio Sampedro, Antonio Sorlózano, Juan de Dios Luna del Castillo, Antonio Jimenez-Pacheco, Consuelo Miranda-Casas |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Imipenem
medicine.medical_specialty Epidemiology medicine.drug_class Antibiotics Microbial Sensitivity Tests Urine Fosfomycin Enterococcus faecalis Microbiology Internal medicine Drug Resistance Bacterial medicine Humans Retrospective Studies Bacteria biology business.industry Health Policy Public Health Environmental and Occupational Health Bacterial Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Hospitals Ciprofloxacin Infectious Diseases Spain Amikacin Nitrofurantoin Epidemiological Monitoring Urinary Tract Infections business Cefuroxime medicine.drug |
| Zdroj: | American Journal of Infection Control. 42:1033-1038 |
| ISSN: | 0196-6553 |
| DOI: | 10.1016/j.ajic.2014.06.013 |
| Popis: | Background We conducted a retrospective analysis on the identification and antibiogram of all bacteria isolated from urine samples with microbiological confirmation of urinary tract infection (UTI) in a Spanish reference hospital over a 7-year period. Methods A retrospective analysis was performed of the identification and antibiogram data. Results A total of 31,758 uropathogens were isolated. Escherichia coli accounted for the majority (55.2%) of these, followed by Enterococcus faecalis (18.0%) and Klebsiella spp (10.3%). The highest E coli susceptibility rates were to imipenem (93.0%-99.8%), amikacin (97.3%-99.5%), nitrofurantoin (96.7%-98.9%), and fosfomycin (95.3%-100%), and the lowest were to cefuroxime (67.8%-86.4%), ciprofloxacin (61.2%-69.8%), and co-trimoxazole (55.0%-65.5%). We highlight the overall high activity of imipenem, piperacillin-tazobactam, nitrofurantoin, and fosfomycin on isolates versus the low activity of fluoroquinolones, co-trimoxazole, or cephalosporins. The activity of amoxicillin-clavulanic acid and fosfomycin decreased significantly over the 7-year study period. Conclusions Imipenem and piperacillin-tazobactam appear to be good options for the empiric treatment of UTI acquired in hospital or requiring hospitalization, whereas nitrofurantoin and fosfomycin can be first-choice antibiotics for the treatment of uncomplicated community-acquired cystitis. However, surveillance studies are required to detect resistance to these antibiotics, given that an increase in uropathogen resistance rates may contraindicate its future use in empiric UTI therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect