Upregulation of Astrocytic Leptin Receptor in Mice with Experimental Autoimmune Encephalomyelitis

Autor: Xiaojun Wu, Abba J. Kastin, Hung Hsuchou, Pramod K. Mishra, Weihong Pan
Rok vydání: 2012
Předmět:
Leptin
medicine.medical_specialty
Encephalomyelitis
Autoimmune
Experimental
Transcription
Genetic
Encephalomyelitis
Hypothalamus
Intermediate Filaments
Mice
Inbred Strains
Nerve Tissue Proteins
Hippocampus
Article
Mice
Cellular and Molecular Neuroscience
Downregulation and upregulation
Internal medicine
medicine
Animals
Gliosis
RNA
Messenger
Myelin Proteolipid Protein
Receptor
Neurons
Leptin receptor
Glial fibrillary acidic protein
biology
digestive
oral
and skin physiology
Experimental autoimmune encephalomyelitis
Convalescence
General Medicine
medicine.disease
Peptide Fragments
Up-Regulation
Endocrinology
Gene Expression Regulation
nervous system
Organ Specificity
Astrocytes
biology.protein
Receptors
Leptin
medicine.symptom
Protein Processing
Post-Translational
hormones
hormone substitutes
and hormone antagonists
Zdroj: Journal of Molecular Neuroscience. 49:446-456
ISSN: 1559-1166
0895-8696
Popis: The detrimental role of leptin in experimental autoimmune encephalomyelitis (EAE) is opposite to its neuroprotective role in other neuropathologies. We hypothesize that a shifted cellular distribution of leptin receptors underlies the differential effects of leptin. A robust increase of ObR immunoreactivity was seen along glial fibrillary acidic protein (GFAP)(+) intermediate filaments in reactive astrocytes in the hippocampus and hypothalamus of mice with EAE. Although astrocyte-specific GFAP mRNA and protein were both increased, ObRa mRNA was elevated only after resolution of EAE symptoms, and ObRb mRNA was even decreased at the peak time of symptoms of EAE. A cell type-specific action of leptin may underlie its differential effects.
Databáze: OpenAIRE
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