Unravelling the biological activities of the Byttneria pilosa leaves using experimental and computational approaches
| Autor: | Md. Nazim Uddin Chy, Adnan, Muminul Hoque, Kamruzzaman, Shabnur Mahmud, Arkajyoti Paul, Tahmina Akter Bristy, Mifta Ahmed Jyoti, Talha Bin Emran, Mir Ezharul Hossain, Jesus Simal-Gandara, Niloy Barua, Mohammad Shafaet Hossain |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.drug_class
3209.04 Medicamentos Naturales medicine.medical_treatment Analgesic Pharmaceutical Science Pharmacology 01 natural sciences Anxiolytic Anti-inflammatory Analytical Chemistry lcsh:QD241-441 03 medical and health sciences lcsh:Organic chemistry In vivo Drug Discovery medicine Physical and Theoretical Chemistry Antidote 3209.07 Fitofármacos 030304 developmental biology ADME anti-inflammatory 0303 health sciences Thiopental Sodium Chemistry Byttneria pilosa Organic Chemistry Biological activity analgesic 0104 chemical sciences 010404 medicinal & biomolecular chemistry anti-diarrheal neuropharmacological Chemistry (miscellaneous) Molecular Medicine 5101.13 Medicina Tradicional anxiolytic |
| Zdroj: | Investigo. Repositorio Institucional de la Universidade de Vigo Universidade de Vigo (UVigo) Molecules Volume 25 Issue 20 Molecules, Vol 25, Iss 4737, p 4737 (2020) |
| Popis: | Byttneria pilosa is locally known as Harijora, and used by the native hill-tract people of Bangladesh for the treatment of rheumatalgia, snake bite, syphilis, fractured bones, elephantiasis and an antidote for poisoning. The present study was carried out to determine the possible anti-inflammatory, analgesic, neuropharmacological and anti-diarrhoeal activity of the methanol extract of B. pilosa leaves (MEBPL) through in vitro, in vivo and in silico approaches. In the anti-inflammatory study, evaluated by membrane stabilizing and protein denaturation methods, MEBPL showed a significant and dose dependent inhibition. The analgesic effect of MEBPL tested by inducing acetic acid and formalin revealed significant inhibition of pain in both tests. During the anxiolytic evaluation, the extract exhibited a significant and dose-dependent reduction of anxiety-like behaviour in mice. Similarly, mice treated with MEBPL demonstrated dose-dependent reduction in locomotion effect in the open field test and increased sedative effect in the thiopental sodium induced sleeping test. MEBPL also showed good anti-diarrheal activity in both castor oil induced diarrheal and intestinal motility tests. Besides, a previously isolated compound (beta-sitosterol) exhibited good binding affinity in docking and drug-likeliness properties in ADME/T studies. Overall, B. pilosa is a biologically active plant and could be a potential source of drug leads, which warrants further advanced study. |
| Databáze: | OpenAIRE |
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