Development of a Concise Rhodamine-Formylhydrazine Type Fluorescent Probe for Highly Specific and Ultrasensitive Tracing of Basal HOCl in Live Cells and Zebrafish

Autor: Wenlong Sheng, Yanan Chen, Zihan Zhuang, Xue Zhang, Pan Jia, Hanchuang Zhu, Caiyun Liu, Zilu Li, Chen Yu, Dongmei Liu, Baocun Zhu, Yamin Yu
Rok vydání: 2019
Předmět:
Zdroj: ACS sensors. 4(8)
ISSN: 2379-3694
Popis: Hypochlorous acid (HOCl) has received special attention by virtue of its pivotal antimicrobial nature, and the appropriate amount of HOCl is beneficial to innate immunity of host to cope with microbial invasion. However, the uncontrollable accumulation of HOCl is implicated in many human diseases and even cancers. Thus, to determine its deeper biological functions, it is significantly important to specifically monitor intracellular HOCl in biosystems. Herein, we rationally designed a simple fluorescent probe
Databáze: OpenAIRE