The cardiac effects of therapeutic plasma concentrations of imipramine
| Autor: | J. T. Bigger, James M. Perel, Alexander H. Glassman, Elsa-Grace V. Giardina, Shepard J. Kantor |
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| Rok vydání: | 1978 |
| Předmět: |
Drug
Adult medicine.medical_specialty Imipramine media_common.quotation_subject Disease Orthostatic vital signs Electrocardiography Hypotension Orthostatic Heart Conduction System Internal medicine medicine Humans Imipramine Hydrochloride media_common Aged chemistry.chemical_classification business.industry Depression Heart Middle Aged Psychiatry and Mental health chemistry Plasma concentration Cardiology Antidepressant business medicine.drug Tricyclic |
| Zdroj: | The American journal of psychiatry. 135(5) |
| ISSN: | 0002-953X |
| Popis: | The authors studied the effects of imipramine hydrochloride at plasma concentrations associated with antidepressant activity in seven patients hospitalized for severe depressive illness. They found that the drug usually produced prolongation of intraventricular cardiac conduction. Although this was generally well tolerated, the authors suggest that patients with preexisting conduction system disease may be at increased risk when taking tricyclic antidepressants. They feel that the orthostatic hypotension seen in all seven patients represents a potentially serious problem with tricyclic antidepressants. They discuss the antiarrhythmic properties associated with imipramine and significant interactions between imipramine and drugs taken by patients with cardiovascular disease. |
| Databáze: | OpenAIRE |
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