Metabolic Response of Adult Male Offspring Rats to Prenatal Caffeine Exposure
| Autor: | Despina Perrea, Panagiotis Konstantopoulos, Emmanouil Pikoulis, Nikolaos Kavantzas, Helen Sarlanis, Laskarina-Maria Korou, Ioannis S. Vlachos, Ioanna Mastroleon, Vasilios Pergialiotis |
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| Rok vydání: | 2020 |
| Předmět: |
Adult male
Offspring Physiology 030204 cardiovascular system & hematology lipids 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine gestation medicine rat caffeine Pregnancy business.industry Endocrinology/Diabetes/Metabolism General Engineering blood pressure Fructose Lipid metabolism medicine.disease Blood pressure chemistry Obstetrics/Gynecology Gestation Anatomy Caffeine business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| DOI: | 10.7759/cureus.7006 |
| Popis: | Caffeine is the most widely consumed psychoactive substance, with recommendations from health associations and regulatory bodies for limiting caffeine consumption during pregnancy being increasingly common. Prenatal exposure to caffeine has been shown to increase the risk of developing abnormalities in lipid metabolism in adult life. We further investigated the effect of prenatal caffeine exposure (PCE) (20 mg/kg of body weight) on the metabolic “reserve” of male Sprague Dawley offspring fed on a high fructose diet in adult life. Male adult PCE offspring were assigned to four groups; Nw and Nf: offspring of control mothers (N group of mothers), having received tap water or high fructose water respectively; Cw and Cf: offspring exposed to caffeine during gestation (C group of mothers) and receiving tap water or a high fructose water solution, respectively. Cf rats presented increased serum triglyceride level, as well as raised systolic and diastolic blood pressure levels, together with extensive renal tissue oedema in adulthood, compared to the other groups (p |
| Databáze: | OpenAIRE |
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