Performance of the systemic lupus erythematosus risk probability index in a cohort of undifferentiated connective tissue disease
| Autor: | Abdulsamet Erden, Hakan Apaydın, Antonis Fanouriakis, Serdar Can Güven, Berkan Armagan, Pınar Akyüz Dağlı, Hatice Ecem Konak, Bünyamin Polat, Ebru Atalar, Serdar Esmer, Özlem Karakaş, Bahar Özdemir, Mehmet Akif Eksin, Ahmet Omma, Orhan Kücüksahin, George K Bertsias, Dimitrios T Boumpas |
|---|---|
| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Rheumatology. 61:3606-3613 |
| ISSN: | 1462-0332 1462-0324 |
| Popis: | Objectives We sought to evaluate the performance of the SLE Risk Probability Index (SLERPI) for identification of SLE in a large cohort of patients with UCTD. Methods The SLERPI was applied in a cohort of patients who met classification criteria for UCTD and did not fulfil any classification criteria for other defined CTD including SLE. Patients with a SLERPI score of >7 were ‘diagnosed’ as SLE. Patients diagnosed with SLE and those not were compared in terms of disease characteristics and index parameters. Results A total of 422 patients with UCTD were included in the study. Median (interquartile range) SLERPI was 4.25 (2.5) points, while 39 (9.2%) patients had a SLERPI score >7 and were diagnosed as SLE. Patients with younger age (P = 0.026) and presence of malar rash (P 500 mg/24 h (P = 0.001), thrombocytopenia (P = 0.009) or autoimmune haemolytic anaemia (P Conclusion SLERPI enabled a significant proportion of patients to be identified as SLE in our UCTD cohort. This new probability index may be useful for early identification of SLE among patients with signs of CTD without fulfilling any definite criteria set. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|