Generation of endoderm lineages from pluripotent stem cells
| Autor: | Jake Leighton, Pei Wang, Han Wang, Mara O'Sullivan, Xie Luo |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Pluripotent Stem Cells
0301 basic medicine Embryology Pathology medicine.medical_specialty Biomedical Engineering Embryoid body Biology Regenerative medicine 03 medical and health sciences medicine Animals Humans Cell Lineage Induced pluripotent stem cell Cells Cultured Endoderm Cell Differentiation Embryonic stem cell Cell biology 030104 developmental biology medicine.anatomical_structure Amniotic epithelial cells embryonic structures Stem cell Definitive endoderm |
| Zdroj: | Regenerative Medicine. 12:77-89 |
| ISSN: | 1746-076X 1746-0751 |
| DOI: | 10.2217/rme-2016-0086 |
| Popis: | Definitive endoderm is the cellular precursor to respiratory- and digestive-related organs such as lungs, stomach, liver, pancreas and intestine. Endodermal lineage cells derived from pluripotent stem cells (PSCs) in vitro are a potentially unlimited resource for regenerative medicine. These cells are useful tools for studying the physiology, pathogenesis and medical therapies involving these tissues, and great progress has been achieved in PSCs differentiation protocols. In this review, we will focus on the most common and/or advanced differentiation strategies currently used in generating endodermal lineage cells from PSCs. A brief discussion about the effect of early definitive endoderm differentiation on the final development products will follow. |
| Databáze: | OpenAIRE |
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