Afrostyrax lepidophyllus extracts exhibit in vitro free radical scavenging, antioxidant potential and protective properties against liver enzymes ion mediated oxidative damage

Autor: Bruno Moukette Moukette, Eustace Berinyuy, Jeanne Ngogang, Constant Anatole Pieme, Prosper Cabral Nya Biapa, Vicky Jocelyne Ama Moor
Rok vydání: 2015
Předmět:
Antioxidant
Afrostyrax lepidophyllus
DPPH
medicine.medical_treatment
Flavonoid
Non-timber forest product
Antioxidants
Trees
Lipid peroxidation
chemistry.chemical_compound
Medicine(all)
chemistry.chemical_classification
Principal Component Analysis
ABTS
biology
Free Radical Scavengers
General Medicine
Catalase
Spice
Liver
Biochemistry
Plant Bark
Colorimetry
Research Article
Free Radicals
Scavenging activity
Nitric Oxide
General Biochemistry
Genetics and Molecular Biology
Superoxide dismutase
Inhibitory Concentration 50
Picrates
medicine
Animals
Benzothiazoles
Rats
Wistar
Peroxidase
Flavonoids
Ions
Molybdenum
Ethanol
Phenol
Hydroxyl Radical
Plant Extracts
Superoxide Dismutase
Biochemistry
Genetics and Molecular Biology(all)
Biphenyl Compounds
Polyphenols
Rats
Oxygen
chemistry
Polyphenol
biology.protein
Lipid Peroxidation
Sulfonic Acids
Zdroj: BMC Research Notes
ISSN: 1756-0500
DOI: 10.1186/s13104-015-1304-8
Popis: Background Several studies described the phytochemical constituents of plants in relation with the free radical scavenging property and inhibition of lipid peroxidation. This study investigated the in vitro antioxidant property, and the protective effects of ethanolic and aqueous ethanol extract of the leaves and barks of Afrostyrax lepidophyllus (Huaceae) against ion mediated oxidative damages. Methods Four extracts (ethanol and aqueous-ethanol) from the leaves and barks of A. lepidophyllus were used in this study. The total phenols content, the antiradical and antioxidant properties were determined using standard colorimetric methods. Results The plant extracts had a significant scavenging potential on the 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydroxyl (OH), nitrite oxide (NO) and 2,2-azinobis (3-ethylbenzthiazoline)-6-sulfonic acid (ABTS) radicals with the IC50 varied between 47 and 200 µg/mL depending on the part of plant and the type of extract. The ethanol extract of A. lepidophyllus bark (GEE) showed the highest polyphenolic (35.33 ± 0.29) and flavonoid (12.00 ± 0.14) content. All the tested extracts demonstrated a high protective potential with the increased of superoxide dismutase, catalase and peroxidase activities. Conclusion Afrostyrax lepidophyllus extracts exhibited higher antioxidant potential and significant protective potential on liver enzymes. Electronic supplementary material The online version of this article (doi:10.1186/s13104-015-1304-8) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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