Comparative studies on the structural phosphoproteins of mammalian type C viruses
| Autor: | M. B. Gardner, Bijay K. Pal, R.M. McAllister, Pradip Roy-Burman |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Threonine
Virus Cultivation viruses Immunology Chemical Fractionation Biology Microbiology Virus Serine Mice Viral Proteins chemistry.chemical_compound Virology Animals Electrophoresis Paper Woolly monkey sarcoma virus Hominidae Haplorhini Phosphoproteins Molecular biology Rats Molecular Weight Mouse sarcoma virus Retroviridae Biochemistry chemistry Insect Science Phosphoprotein Phosphoserine Cats Phosphothreonine Electrophoresis Polyacrylamide Gel Peptides Papio Research Article |
| Zdroj: | Journal of Virology. 16:123-131 |
| ISSN: | 1098-5514 0022-538X |
| DOI: | 10.1128/jvi.16.1.123-131.1975 |
| Popis: | The major phosphoprotein common to woolly monkey sarcoma virus, gibbon ape lymphosarcoma virus, and type C viruses of the lower mammalian species (mouse, rat, cat), with the exception of the endogenous cat virus (RD-114), is the polypeptide of about 12,000 molecular weight. The protein-phosphate bond in this polypeptide of several viruses is of the phosphoserine variety excepting gibbon ape virus, which contains both phosphoserine and phosphothreonine. The primary phosphoprotein of RD-114 virus and the endogenous baboon type C virus, on the other hand, is the polypeptide of about 15,000 molecular weight which contains phosphothreonine as its phosphoamino acid. A second major phosphoprotein of molecular weight of 10,000 is detected only in viruses genetically related to rat species including those derived from the RPL cell line, from Sprague-Dawley rat embryo cells, and the Kirsten mouse sarcoma virus which was recovered from a mouse erythroblastosis virus after in vivo propagation through rat. These phosphorylated polypeptides of molecular weight 15,000, 12,000, or 10,000 are present in the virion structure in several different but nonrandom phosphorylated states. |
| Databáze: | OpenAIRE |
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