Lung Adenocarcinoma with Paraneoplastic Hyper-Eosinophilia Not Responding To Pembrolizumab
| Autor: | Maria Kozah, Salwa A Koubaissi, Hisham Wehbe |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Pulmonary and Respiratory Medicine Poor prognosis medicine.medical_treatment neoplasms Case Report Pembrolizumab adenocarcinoma of lung neoplasm metastasis 03 medical and health sciences Diseases of the respiratory system 0302 clinical medicine medicine Eosinophilia Diseases of the circulatory (Cardiovascular) system Lung RC705-779 business.industry Immunotherapy respiratory system medicine.disease respiratory tract diseases 030104 developmental biology medicine.anatomical_structure pleura 030220 oncology & carcinogenesis RC666-701 Cancer research Adenocarcinoma medicine.symptom Cardiology and Cardiovascular Medicine business eosinophilia Metastatic Lung Adenocarcinoma |
| Zdroj: | Clinical Medicine Insights: Circulatory, Respiratory and Pulmonary Medicine, Vol 15 (2021) Clinical Medicine Insights. Circulatory, Respiratory and Pulmonary Medicine |
| ISSN: | 1179-5484 |
| Popis: | Background: Paraneoplastic hyper-eosinophilia associated with metastatic lung adenocarcinoma is a rare finding and has been associated with a poor prognosis when present. Early hyper-eosinophilia appearing following non-small cell lung cancer (NSCLC) treatment with immune checkpoint inhibitors (ICI) has been previously reported with contradictory outcomes. Case summary: We present the case of an elderly man with newly diagnosed metastatic lung adenocarcinoma and baseline hyper-eosinophilia, treated with pembrolizumab, and showing evidence of significant and rapid disease progression suggestive of hyper-progressive disease, worsening baseline hyper-eosinophilia, and a fatal outcome within 1 month of therapy initiation. Conclusion: Pre-treatment hyper-eosinophilia could represent a predictive factor of an unfavorable response to ICI treatment in cases of NSCLC. Additional similar cases are needed to draw a more conclusive relationship. |
| Databáze: | OpenAIRE |
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