Deficient passive and one-way active avoidance acquisition following medial forebrain bundle lesions in rats
| Autor: | John P. Heybach, Gary D. Coover |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Telencephalon
medicine.medical_specialty Differential Threshold Drinking Behavior Serotonergic 5-Hydroxytryptophan Internal medicine medicine Avoidance Learning Animals Fear learning Diencephalon Medial forebrain bundle business.industry Septal nuclei Hypodipsia General Medicine Feeding Behavior Control subjects Rats medicine.anatomical_structure Endocrinology Septal Nuclei Serotonin Passive avoidance business |
| Zdroj: | Journal of comparative and physiological psychology. 90(5) |
| ISSN: | 0021-9940 |
| Popis: | Cathodal electrolytic lesions of the medial forebrain bundle (MFB) at posterior hypothalamic levels in male hooded rats produced a mild, transient hypodipsia and lowered jump thresholds to footshock. The lesions produced marked deficits in passive avoidance performance in a paradigm that paired discrete, linearly incrementing footshock intensities with contact of a water spout following 48 hr of water deprivation. Intraperitoneal injections of DL-5-hydroxytryptophan (75 mg/kg), the immediate metabolic precursor of serotonin, had no effect on the passive avoidance performance of either experimental or operated control subjects. Lesions of the MFB also resulted in deficient acquisition in a one-trial step-through passive avoidance paradigm not using motivation to drink and caused a severe acquisition deficit in a one-way active avoidance task. Lesions of the septal nuclei produced lowered jump thresholds but did not affect acquisition in the first passive avoidance task. The results are interpreted as indicating a lesion-induced deficiency in fear learning, independent of the serotonergic functions of the MFB. |
| Databáze: | OpenAIRE |
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