Toxicity of Trimethyltin and Dimethyltin in Rats and Mice
| Autor: | James R. Olson, Xuefeng Ren, Shenglai Liu, Xiaojiang Tang, Guanchao Lai, Zhong Zhiyong, Xin Wu, Banghua Wu, Amber M. Dubois, Hongbin Gao, Zhihong Gong, Gang Sui, Zhongning Lin |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Chronic exposure Neurotoxicity Syndrome Health Toxicology and Mutagenesis Hypokalemia Environmental media Pharmacology Toxicology Rats Sprague-Dawley Mice Organotin Compounds medicine Animals Trimethyltin Compounds Chemistry Blood potassium level Neurotoxicity General Medicine medicine.disease Pollution Acute toxicity Rats Toxicity Environmental Pollutants Female Neurotoxicity Syndromes medicine.symptom human activities |
| Zdroj: | Bulletin of Environmental Contamination and Toxicology. 90:626-633 |
| ISSN: | 1432-0800 0007-4861 |
| DOI: | 10.1007/s00128-013-0975-x |
| Popis: | Extensive uses of methyltin compounds in polyvinyl chloride (PVC) production have led to a dramatic increase of occupational-related methyltin poisoning accidents and the widespread contamination of methyltins in various environmental media. Here, we conducted studies to compare the acute toxicity induced by trimethyltin (TMT) and dimethyltin (DMT), and investigated the cumulative toxic effects of TMT in rats and mice. Neurobehavioral changes were observed in rats and mice treated with either DMT or TMT, but we also observed that both TMT and DMT exposure in rats significantly lowered the blood potassium level. Moreover, the cumulative toxic coefficient factor of TMT was 1.7 in rats versus 3.8 in mice, suggesting a high cumulative risk for rats and a moderate risk for mice. In summary, we demonstrated that acute and chronic exposure to methyltin compounds induced neurotoxicity and hypokalemia. Moreover, our study suggests that TMT can accumulate in the body and pose a risk for workers chronically exposed to a low dose of TMT. |
| Databáze: | OpenAIRE |
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