Hepatitis B surface antigen associated nephrotic syndrome
| Autor: | M.B. Abdurrahman, S. Ramia, J.B. Lynch, A.T.H. Elidrissy |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome Glomerulonephritis Membranoproliferative 030231 tropical medicine Saudi Arabia Enzyme-Linked Immunosorbent Assay medicine.disease_cause Glomerulonephritis Membranous Gastroenterology Pathogenesis 03 medical and health sciences 0302 clinical medicine Membranous nephropathy 030225 pediatrics Internal medicine medicine Humans Family Hepatitis B e Antigens Hepatitis B Antibodies Child Pathological Hepatitis B virus Hepatitis B Surface Antigens medicine.diagnostic_test business.industry Infant Glomerulonephritis Hepatitis B medicine.disease Child Preschool Pediatrics Perinatology and Child Health Female Renal biopsy business Nephrotic syndrome |
| Zdroj: | Annals of Tropical Paediatrics. 8:157-161 |
| ISSN: | 1465-3281 0272-4936 |
| DOI: | 10.1080/02724936.1988.11748560 |
| Popis: | Hepatitis B virus (HBV) has been reported in association with the nephrotic syndrome from different parts of the world, but its role as a cause of the pathological findings of nephrotic syndrome is still controversial. We report seven nephrotic children with positive hepatitis B markers in which members of their families were also positive for the markers but without clinical, renal or hepatic involvement. Four showed haematuria at onset and three developed hypertension later in the course of the disease. Only two were responsive to steroid therapy. Renal biopsy was performed in four, of whom three showed membranous nephropathy and the other showed mesangioproliferative glomerulonephritis. Four patients developed end-stage renal disease. We conclude that in our environment HBV, when detected in children with nephrotic syndrome, should not be considered as a chance finding, but may have a definite role in its pathogenesis. Moreover, the prognosis of HBV-associated nephrotic syndrome appears poor. |
| Databáze: | OpenAIRE |
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