Butyrylcholinesterase Activity, Cardiovascular Risk Factors, and Mortality in Middle-Aged and Elderly Men and Women in Jerusalem
| Autor: | Bella Adler, Ronit Calderon-Margalit, Joseph H. Abramson, Jeremy D. Kark, Jaime Gofin |
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| Rok vydání: | 2006 |
| Předmět: |
Blood Glucose
Male medicine.medical_specialty Clinical Biochemistry Population Coronary Disease Overweight Risk Factors Internal medicine Humans Medicine Body Weights and Measures Israel Risk factor education Homocysteine Life Style Aged Aged 80 and over education.field_of_study business.industry Biochemistry (medical) Hazard ratio Middle Aged medicine.disease Lipids Obesity Middle age Cross-Sectional Studies Endocrinology Socioeconomic Factors Butyrylcholinesterase Multivariate Analysis Regression Analysis Female medicine.symptom business Body mass index Blood sampling |
| Zdroj: | Clinical Chemistry. 52:845-852 |
| ISSN: | 1530-8561 0009-9147 |
| DOI: | 10.1373/clinchem.2005.059857 |
| Popis: | Background: The association of butyrylcholinesterase (BuChE) with Alzheimer disease and the association of this disease with cardiovascular risk factors raise interest in the association of BuChE activity with cardiovascular risk factors and mortality. Methods: A baseline cross-sectional study was conducted between 1985 and 1987, encompassing residents ≥50 years of age living in a Jewish neighborhood in western Jerusalem. Interviews were followed by examinations and nonfasting blood sampling (available for 1807 participants). Follow-up data to April 1996 on mortality and causes of death were obtained through record linkage with the Israeli Population Registry. Results: BuChE activity was inversely related to age and was positively associated with serum concentrations of albumin (r = 0.35; P Conclusions: This is the first study to report on the association between BuChE and mortality. The relatively strong association of BuChE with serum lipid and albumin concentrations requires elucidation. Our results suggest that low BuChE activity may be a nonspecific risk factor for mortality in the elderly. |
| Databáze: | OpenAIRE |
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