Modulation of the human electro-cerebellogram (ECeG) during vestibular and optokinetic stimulation
| Autor: | Neil P. M. Todd, Sendhil Govender, James G. Colebatch |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cerebellum Purkinje cell Acceleration Action Potentials Context (language use) Electroencephalography Inhibitory postsynaptic potential 03 medical and health sciences 0302 clinical medicine medicine Humans Evoked Potentials Vestibular system Neurons medicine.diagnostic_test Chemistry General Neuroscience Optokinetic reflex 030104 developmental biology medicine.anatomical_structure Scalp Neuroscience 030217 neurology & neurosurgery Photic Stimulation |
| Zdroj: | Neuroscience letters. 712 |
| ISSN: | 1872-7972 |
| Popis: | We have recently shown that it is possible to record vestibular cerebellar evoked potentials (VsCEPs) in the form of a contralateral short-latency biphasic positive-negative wave with surface electrodes placed over the posterior fossa and, in parallel with this, the spontaneous electrocerebellogram (or ECeG). VsCEPs were further shown to exhibit considerable plasticity depending on visual context and in this article we show additionally that the ECeG power and cerebro-cerebellar coherence which accompanies the VsCEPs also changes systematically during vestibular and optokinetic stimuli. In a sample of nine healthy human subjects, half of whom had VsCEPs, we recorded in parallel the ECeG and for comparison the EEG from central scalp sites. The results showed that during vection with vestibular stimulation there is actually a reduction in the power of the ECeG accompanied by an increase in cerebro-cerebellar coherence, both of which correlate with the subjective sensation of vection. Only the VsCEPs present group showed the significant power reduction and increase in coherence, indicating a link between the VsCEP and plasticity in the ECeG. We suggest that these data are consistent with a human cerebro-cerebellar network associated with control of the VOR. The network exhibits the plasticity expected from the known inhibitory properties of Purkinje cells and the pausing of spontaneous Purkinje cell activity following a climbing-fibre evoked response with conjunctive inputs from the mossy-fibre system. |
| Databáze: | OpenAIRE |
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