Conservation of the MORF4 related gene family: identification of a new chromo domain subfamily and novel protein motif
| Autor: | Michael J. Bertram, Olivia M. Pereira-Smith |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Subfamily
Databases Factual Protein family Amino Acid Motifs Molecular Sequence Data Protein domain Sequence alignment Biology Chromatin remodeling Conserved sequence Mice Dogs Genetics Animals Humans Gene family Amino Acid Sequence Conserved Sequence Phylogeny Binding Sites Sequence Homology Amino Acid DNA Haplorhini General Medicine biology.organism_classification Chromatin Rats Blotting Southern Cattle Rabbits Drosophila melanogaster Chickens Sequence Alignment Transcription Factors |
| Zdroj: | Gene. 266:111-121 |
| ISSN: | 0378-1119 |
| DOI: | 10.1016/s0378-1119(01)00372-9 |
| Popis: | The seven member, human MORF4 related gene (MRG) family was recently identified based on the ability of Mortality factor on chromosome 4 (MORF4) to induce replicative senescence in immortal cell lines assigned to complementation group B (Bertram et al., 1999. Mol. Cell Biol. 19, 1479-1485). Initial computer based similarity searches identified human retinoblastoma binding protein 1 (RBP-1), Drosophila melanogaster male specific lethal-3 (Msl-3), S. pombe altered polarity-13 (Alp13) and S. cerevisiae Eaf3p, a component of the yeast NuA4 HAT complex (Galarneau et al., 2000. Mol. Cell 5, 927-937), as having similarity to the human MRG protein family. This suggested that the MRG family might be found in multiple species, and analysis of other homologs would provide functional and evolutionary insights into this gene family. Here, we report that MRG family members are present in twenty-three species based on molecular assays and sequence similarity searches. The new family members were divided into two groups based on similarity to the predominant human MRG family members, MRG15 and MRGX. The family members similar to MRG15 define a new, highly conserved subsection of the chromo domain superfamily. Additionally, conservation in the C-terminal two thirds of all the MRG family members and the Drosophila and human MSL-3 proteins defines a new protein domain, the MRG domain. These results indicate a highly conserved role for the MRG family in transcriptional regulation via chromatin remodeling by histone acetylation. |
| Databáze: | OpenAIRE |
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