Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1
| Autor: | Emily A. Aery Jones, Antara Rao, Misha Zilberter, Biljana Djukic, Jason S. Bant, Anna K. Gillespie, Nicole Koutsodendris, Maxine Nelson, Seo Yeon Yoon, Ky Huang, Heidi Yuan, Theodore M. Gill, Yadong Huang, Loren M. Frank |
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| Rok vydání: | 2021 |
| Předmět: |
Male
hippocampus Medical Physiology Action Potentials CA3 somatostatin Inbred C57BL Article CA1 General Biochemistry Genetics and Molecular Biology Mice 03 medical and health sciences 0302 clinical medicine Interneurons parvalbumin Entorhinal Cortex Animals Hippocampal dentate gyrus GABAergic Neurons CA1 Region Hippocampal 030304 developmental biology 0303 health sciences musculoskeletal neural and ocular physiology slow gamma fungi Neurosciences CA1 Region CA3 Region CA3 Region Hippocampal sharp-wave ripple Mice Inbred C57BL GABAergic interneuron nervous system theta Dentate Gyrus fast gamma Female Biochemistry and Cell Biology Somatostatin 030217 neurology & neurosurgery |
| Zdroj: | Cell reports, vol 37, iss 13 Cell Rep |
| ISSN: | 2211-1247 |
| Popis: | Specific classes of GABAergic neurons play specific roles in regulating information processing in the brain. In the hippocampus, two major classes – parvalbumin-expressing (PV(+)) and somatostatin-expressing (SST(+)) – differentially regulate endogenous firing patterns and target subcellular compartments of principal cells. How these classes regulate the flow of information throughout the hippocampus is poorly understood. We hypothesize that PV(+) and SST(+) interneurons in the dentate gyrus (DG) and CA3 differentially modulate CA3 patterns of output, thereby altering the influence of CA3 on CA1. We find that while suppressing either interneuron class increases DG and CA3 output, the effects on CA1 were very different. Suppressing PV(+) interneurons increases local field potential signatures of coupling from CA3 to CA1 and decreases signatures of coupling from entorhinal cortex to CA1; suppressing SST(+) interneurons has the opposite effect. Thus, DG and CA3 PV(+) and SST(+) interneurons bidirectionally modulate the flow of information through the hippocampal circuit. |
| Databáze: | OpenAIRE |
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