Antifungal Activity, Toxicity and Chemical Composition of the Essential Oil of Coriandrum sativum L. Fruits
| Autor: | Vanessa A. Queiroz, Raquel Oliveira dos Santos Fontenelle, Manoel Alves de Souza Neto, Carolina Sidrim de Paula Cavalcante, Nadja S. Vila-Nova, Bruna V. Soares, Edy Sousa de Brito, Christiana M. C. Pereira, Marcos Fábio Gadelha Rocha, Débora de Souza Collares Maia Castelo-Branco, Selene Maia de Morais, Erika H.S. Brito |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Antifungal Agents
linalool Coriandrum Pharmaceutical Science Microbial Sensitivity Tests Article essential oil Microsporum canis Analytical Chemistry law.invention Diffusion chemistry.chemical_compound Minimum inhibitory concentration Sativum Linalool law Toxicity Tests Drug Discovery Botany Oils Volatile Animals Microsporum Food science Physical and Theoretical Chemistry Coriandrum sativum Candida spp Essential oil Candida biology Organic Chemistry Broth microdilution biology.organism_classification Artemia salina chemistry Chemistry (miscellaneous) Fruit Molecular Medicine Artemia |
| Zdroj: | Molecules; Volume 17; Issue 7; Pages: 8439-8448 Molecules |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules17078439 |
| Popis: | The aims of this study were to test the antifungal activity, toxicity and chemical composition of essential oil from C. sativum L. fruits. The essential oil, obtained by hydro-distillation, was analyzed by gas chromatography/mass spectroscopy. Linalool was the main constituent (58.22%). The oil was considered bioactive, showing an LC₅₀ value of 23 μg/mL in the Artemia salina lethality test. The antifungal activity was evaluated against Microsporum canis and Candida spp. by the agar-well diffusion method and the minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were established by the broth microdilution method. The essential oil induced growth inhibition zones of 28 ± 5.42 and 9.25 ± 0.5 for M. canis and Candida spp. respectively. The MICs and MFCs for M. canis strains ranged from 78 to 620 and 150 to 1,250 μg/mL, and the MICs and MFCs for Candida spp strains ranged from 310 to 620 and 620 to 1,250 μg/mL, respectively. C. sativum essential oil is active in vitro against M. canis and Candida spp. demonstrating good antifungal activity. |
| Databáze: | OpenAIRE |
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