A case of recurrent pseudolymphomatous folliculitis: A mimic of cutaneous lymphoma
| Autor: | Gregory M. Fedele, Jennifer M. McNiff, Eun Ji Kwon, Ralph J. Tuthill, Arni Kristjansson, Kord Honda, Howard J. Meyerson, Rebecca C. Tung, Anita C. Gilliam, Klaus Sellheyer |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Pathology Skin Neoplasms CD3 Complex T-Lymphocytes Nose Neoplasms Folliculitis Dermatology Polymerase Chain Reaction Nose neoplasm Cutaneous lymphoma Lymphoid hyperplasia Diagnosis Differential Lymphocytic Infiltrate medicine Pseudolymphoma Humans Histiocyte Gene Rearrangement B-Lymphocytes integumentary system business.industry Gene rearrangement Middle Aged medicine.disease Lymphoma T-Cell Cutaneous Neoplasm Proteins medicine.symptom business |
| Zdroj: | Journal of the American Academy of Dermatology. 60:994-1000 |
| ISSN: | 0190-9622 |
| DOI: | 10.1016/j.jaad.2008.10.010 |
| Popis: | Pseudolymphomatous folliculitis is a rare entity. We present a 62-year-old man with a recurrent solitary nodule on his nose requiring multiple excisions. Microscopic examination of the excisions showed a dense lymphocytic infiltrate containing numerous histiocytes and S100+, CD1a+ dendritic cells that surrounded and infiltrated hypertrophic hair follicles. Diffuse sheets of CD3+ T cells and nodular clusters of CD20+ B cells were also seen. There was normal reactive pattern of follicular centers. Light chain restriction was not detected. T-cell receptor and immunoglobulin heavy chain gene rearrangements by polymerase chain reaction revealed negative findings. A diagnosis of pseudolymphomatous folliculitis was made based on the hypertrophic hair follicles, periadnexal S100+ and CD1a+ dendritic cells, and negative clonal gene rearrangement study findings. This case of recurrent pseudolymphomatous folliculitis is instructive because of the resemblance to cutaneous lymphomas and cutaneous lymphoid hyperplasias, and the need for correct diagnosis to avoid overtreatment of this indolent condition. |
| Databáze: | OpenAIRE |
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