Predictive value of plasma human chorionic gonadotropin measured 14 days after Day-2 single embryo transfer
| Autor: | Lisbeth Prætorius, Anna Oldenburg, Kristine Løssl, Jeanette Bogstad, Anne Zedeler, Claus Yding Andersen, Anja Pinborg, Marie Louise Grøndahl, M Toftager |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent medicine.medical_treatment Intracytoplasmic sperm injection Human chorionic gonadotropin Young Adult 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Pregnancy medicine Humans Chorionic Gonadotropin beta Subunit Human Gynecology 030219 obstetrics & reproductive medicine In vitro fertilisation business.industry Obstetrics Pregnancy Outcome Area under the curve Obstetrics and Gynecology Gestational age General Medicine Embryo Transfer medicine.disease Embryo transfer 030104 developmental biology Area Under Curve Predictive value of tests Female business Biomarkers |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 96:960-967 |
| ISSN: | 0001-6349 |
| DOI: | 10.1111/aogs.13144 |
| Popis: | Introduction Prediction of pregnancy outcome after in vitro fertilization is important for patients and clinicians. Early plasma human chorionic gonadotropin (p-hCG) levels are the best known predictor of pregnancy outcome, but no studies have been restricted to single embryo transfer (SET) of Day-2 embryos. The aim of the present study was to investigate the predictive value of p-hCG measured exactly 14 days after the most commonly used Day-2 SET on pregnancy, delivery, and perinatal outcome. Materials and methods A retrospective analysis of prospectively collected data on 466 women who had p-hCG measured exactly 14 days after Day-2 SET during a randomized trial including 1050 unselected women (aged 18–40 years) undergoing their first in vitro fertilization/ intracytoplasmic sperm injection treatment. Results The p-hCG predicted clinical pregnancy [area under the curve (AUC) 0.953; 95% CI 0.915–0.992] significantly better than ongoing pregnancy (AUC 0.803, 95% CI 0.717–0.890) and delivery (AUC 0.772, 95% CI 0.691–0.854). Women with p-hCG levels in the lowest quartile had significantly lower clinical pregnancy, ongoing pregnancy, and delivery rates (p < 0.001), whereas the pregnancy outcome and post-clinical pregnancy loss remained similar throughout the three highest p-hCG quartiles. The p-hCG level was related to neither birthweight nor gestational age at delivery. Conclusions Clinical pregnancy is significantly better predicted by p-hCG compared with ongoing pregnancy and delivery. Clinical pregnancy rates, ongoing pregnancy rates, and delivery rates remained similar throughout the three highest p-hCG quartiles with no trend towards “the higher the better”. |
| Databáze: | OpenAIRE |
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