Zinc supplementation in rats impairs hippocampal-dependent memory consolidation and dampens post-traumatic recollection of stressful event

Autor: Barbara Monti, Emiliano Peña-Altamira, Antonio Contestabile, Marco Virgili
Přispěvatelé: Contestabile, A, Peña-Altamira, E, Virgili, M, Monti, B.
Jazyk: angličtina
Rok vydání: 2016
Předmět:
0301 basic medicine
Male
Contextual fear conditioning
MAP Kinase Signaling System
Neurogenesis
Hippocampus
Hippocampal formation
Developmental psychology
Stress Disorders
Post-Traumatic
03 medical and health sciences
Glycogen Synthase Kinase 3
0302 clinical medicine
Conditioning
Psychological
medicine
Animals
Pharmacology (medical)
Effects of sleep deprivation on cognitive performance
Rats
Wistar
Phosphorylation
Biological Psychiatry
Memory Consolidation
Pharmacology
Recall
Long-term treatment
Cognition
Fear
Inhibitory avoidance
medicine.disease
Rats
Trace Elements
GSK-3ß
Psychiatry and Mental health
Zinc
030104 developmental biology
Neurology
Synaptic plasticity
Dietary Supplements
Zinc deficiency
Wounds and Injuries
Memory consolidation
Neurology (clinical)
Psychology
Neuroscience
030217 neurology & neurosurgery
Stress
Psychological
Popis: Zinc is a trace element important for synaptic plasticity, learning and memory. Zinc deficiency, both during pregnancy and after birth, impairs cognitive performance and, in addition to memory deficits, also results in alterations of attention, activity, neuropsychological behavior and motor development. The effects of zinc supplementation on cognition, particularly in the adult, are less clear. We demonstrate here in adult rats, that 4 week-long zinc supplementation given by drinking water, and approximately doubling normal daily intake, strongly impairs consolidation of hippocampal-dependent memory, tested through contextual fear conditioning and inhibitory avoidance. Furthermore, the same treatment started after memory consolidation of training for the same behavioral tests, substantially dampens the recall of the stressful event occurred 4 weeks before. A molecular correlate of the amnesic effect of zinc supplementation is represented by a dysregulated function of GSK-3s in the hippocampus, a kinase that participates in memory processes. The possible relevance of these data for humans, in particular regarding post-traumatic stress disorders, is discussed in view of future investigation.
Databáze: OpenAIRE
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