Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication
| Autor: | Lise Bjerrum Thisted, Pernille Envold Bidstrup, Anne Frølich, Christiane Ehlers Mortensen, Susanne Oksbjerg Dalton, Helle Pappot, Katrine Loeppenthin, Christoffer Johansen, Lone Nørgaard Petersen, Ulrik Lassen, Elisabeth Wreford Andersen, Mikkel Bring Christensen, Jytte Ørsted |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Denmark Disease Article Cohort Studies 03 medical and health sciences Cancer epidemiology 0302 clinical medicine Cost of Illness Neoplasms Internal medicine Humans Medicine Registries 030212 general & internal medicine Medical diagnosis Medical prescription Stroke Depression (differential diagnoses) Aged Cancer Aged 80 and over Polypharmacy business.industry Multimorbidity Middle Aged medicine.disease Oncology 030220 oncology & carcinogenesis Female business Cohort study |
| Zdroj: | British Journal of Cancer Loeppenthin, K, Dalton, S O, Johansen, C, Andersen, E, Christensen, M B, Pappot, H, Petersen, L N, Thisted, L B, Frølich, A, Mortensen, C E, Lassen, U, Ørsted, J & Bidstrup, P E 2020, ' Total burden of disease in cancer patients at diagnosis—a Danish nationwide study of multimorbidity and redeemed medication ', British Journal of Cancer, vol. 123, no. 6, pp. 1033-1040 . https://doi.org/10.1038/s41416-020-0950-3 |
| ISSN: | 1532-1827 0007-0920 |
| Popis: | Background Multimorbidity is a growing challenge worldwide. In this nationwide study, we investigated the prevalence of multimorbidity and polypharmacy at the time of diagnosis across 20 cancers. Methods We conducted a nationwide register-based cohort study of all Danish residents with a first primary cancer diagnosed between 1 January 2005 and 31 December 2015. Multimorbidity was defined as one or more of 20 conditions (131 specific diagnoses) registered in the Danish National Patient Registry Results We included 261,745 patients with a first primary cancer, of whom 55% had at least one comorbid condition at diagnosis and 27% had two or more. The most prevalent conditions at the time of cancer diagnosis were cardiovascular disease, chronic obstructive pulmonary disease, diabetes, stroke and depression/anxiety disorder. Polypharmacy was present in one-third of the cancer patients with antihypertensives, anti-thrombotic agents, anti-hyperlipidaemic agents, analgesics and diuretics as the most prevalent redeemed medications. Conclusion Among patients with a newly established cancer diagnosis, 55% had at least one comorbid condition and 32% were exposed to polypharmacy. |
| Databáze: | OpenAIRE |
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