Bone Quality Assessment as Measured by Trabecular Bone Score in Patients With End-Stage Renal Disease on Dialysis
| Autor: | Konstantinos Makris, Maria Pikilidou, Melina Sachinidou, Kalliopi Kotsa, Vasilios Vaios, Vassilios Liakopoulos, Symeon Tournis, Ioannis Chryssogonidis, Michalis Daniilidis, Afroditi Haritanti, Maria P. Yavropoulou |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty alpha-2-HS-Glycoprotein Endocrinology Diabetes and Metabolism medicine.medical_treatment Osteoporosis 030232 urology & nephrology Urology 030209 endocrinology & metabolism End stage renal disease 03 medical and health sciences Absorptiometry Photon 0302 clinical medicine Trabecular bone score Bone Density Renal Dialysis medicine Humans Radiology Nuclear Medicine and imaging Orthopedics and Sports Medicine Dialysis Aged Femoral neck Aged 80 and over Bone mineral Lumbar Vertebrae Femur Neck business.industry Middle Aged medicine.disease Surgery Fibroblast Growth Factors Fibroblast Growth Factor-23 Radius Cross-Sectional Studies medicine.anatomical_structure Case-Control Studies Cancellous Bone Kidney Failure Chronic Female Hemodialysis business Body mass index Osteoporotic Fractures |
| Zdroj: | Journal of Clinical Densitometry. 20:490-497 |
| ISSN: | 1094-6950 |
| Popis: | Patients with end-stage renal disease (ESRD) on maintenance hemodialysis (HD) exhibit osteoporosis and increased fracture risk. Dual-energy X-ray absorptiometry scan measurements and calculation of fracture risk assessment toll score underestimate fracture risk in these patients and do not estimate bone quality. Trabecular bone score (TBS) has been recently proposed as an indirect measure of bone microarchitecture. In this study, we investigated alterations of bone quality in patients with ESRD on HD, using TBS. Fifty patients with ESRD on HD, with a mean age 62 years, and 52 healthy individuals matched for age, body mass index, and gender, were enrolled. All participants had a bone mineral density (BMD) measurement by dual-energy X-ray absorptiometry scan at the lumbar spine, femoral neck, total hip, and 1/3 radius. TBS was evaluated using TBS iNsight. Serum fetuin-A and plasma fibroblast growth factor-23 (FGF-23) (C-terminal) were also measured. Patients on dialysis had significantly lower BMD values at all skeletal sites measured. Plasma FGF-23 levels significantly increased and serum fetuin-Α significantly decreased in patients on dialysis compared with controls. TBS was significantly reduced in patients on dialysis compared with controls (1.11 ± 0.16 vs 1.30 ± 0.13, p |
| Databáze: | OpenAIRE |
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