Anti-parasitic drug discovery takes a giant leap forward
| Autor: | Joseph T. Nickels |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Proteomics
Antiparasitic Agents Antimetabolites Chemistry Drug discovery Anti parasitic Acanthamoeba Cell Biology Computational biology Biochemistry Cell Line Anti-Bacterial Agents Kinetics Sterols Endocrinology Parasitic Sensitivity Tests Drug Discovery Commentary Mutagenesis Site-Directed Humans Phylogeny |
| Zdroj: | J Lipid Res |
| ISSN: | 0022-2275 |
| DOI: | 10.1194/jlr.c094250 |
| Popis: | Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol biosynthesis pathway, cholesta-5,7,22,24-tetraenol (CHT) and ergosta-5,7,22,24(28)-tetraenol (ERGT), and demonstrated their interference in |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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