Amino-substituted p-benzoquinones
| Autor: | Robert K. Y. Zee-Cheng, C. C. Cheng, Abraham E. Mathew |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Chemical Phenomena
Stereochemistry medicine.drug_class Drug Evaluation Preclinical Adenocarcinoma Aminoketone chemistry.chemical_compound Neoplasms Diamine Drug Discovery Anthraquinones Benzoquinones medicine Animals Humans chemistry.chemical_classification Leukemia P388 Chemistry Quinones Biological activity Haloketone Benzoquinone Quinone Naphthalimides Colonic Neoplasms Molecular Medicine Neisseria |
| Zdroj: | Journal of Medicinal Chemistry. 29:1792-1795 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm00159a041 |
| Popis: | Based on the observation of outstanding antineoplastic activity of a number of amino-substituted anthraquinones, thioxanthones, and N-(aminoethyl)-substituted naphthalimides, four types of amino-substituted p-benzoquinones were designed, synthesized, and their biological activity evaluated. Although none of these compounds exhibited inhibitory activity against P388 leukemia, 2,5-bis[[4-[(dimethylamino)methyl]phenyl]amino]-3,6-dibromo-1,4- benzoquinone and the corresponding dichloro compound demonstrated good inhibitory activity against the proliferating human colon adenocarcinoma in vitro. The dichloro compound was also found to be active against the leukemia L1210 screening in vitro. 2,5-Bis[[2-(dimethylamino)ethyl]amino]-1,4-benzoquinone possessed inhibitory activity against Neisseria catarrhali. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|