Adenovirus-derived vectors for prostate cancer gene therapy
| Autor: | Vrij, J., Willemsen, R. A., Lindholm, L., Hoeben, R. C., Giant, Consortium, Bangma, C. H., Barber, C., Behr, J. P., Briggs, S., Carlisle, R., Cheng, W. S., Dautzenberg, I. J., Ridder, C., Dzojic, H., Erbacher, P., Essand, M., Fisher, K., Frazier, A., Georgopoulos, L. J., Jennings, I., Kochanek, S., Koppers-Lalic, D., Kraaij, R., Kreppel, F., Magnusson, M., Maitland, N., Neuberg, P., Nugent, R., Ogris, M., Remy, J. S., Scaife, M., Schenk-Braat, E., Schooten, E., Seymour, L., Slade, M., Szyjanowicz, P., Totterman, T., Uil, T. G., Ulbrich, K., Weel, L., Weerden, W., Wagner, E., Guy Zuber |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Oncology medicine.medical_specialty Pathology conditionally replicating adenovirus polymer-coated adenovirus membrane antigen psma capsid protein-ix t-cell-receptor polyethylene-glycol tumor-cells in-vivo urokinase receptor oncolytic virus Genetic enhancement Genetic Vectors Adenoviridae Prostate cancer Internal medicine Genetics medicine Humans Vector (molecular biology) Adverse effect Molecular Biology Survival rate business.industry Prostatic Neoplasms Cancer Genetic Therapy medicine.disease Oncolytic virus Molecular Medicine Oncolytic Virus Therapy business |
| Zdroj: | Human Gene Therapy, 21(7), 795-805 Scopus-Elsevier |
| Popis: | Prostate cancer is a leading cause of death among men in Western countries. Whereas the survival rate approaches 100% for patients with localized cancer, the results of treatment in patients with metastasized prostate cancer at diagnosis are much less successful. The patients are usually presented with a variety of treatment options, but therapeutic interventions in prostate cancer are associated with frequent adverse side effects. Gene therapy and oncolytic virus therapy may constitute new strategies. Already a wide variety of preclinical studies has demonstrated the therapeutic potential of such approaches, with oncolytic prostate-specific adenoviruses as the most prominent vector. The state of the art and future prospects of gene therapy in prostate cancer are reviewed, with a focus on adenoviral vectors. We summarize advances in adenovirus technology for prostate cancer treatment and highlight areas where further developments are necessary. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|