Expression of Ring Box-1 protein and its relationship with Fuhrman grade and other clinical-pathological parameters in renal cell cancer
| Autor: | Emre Altintas, Serdar Goktas, Ozcan Kilic, Murat Akand, Z. Esin Celik, Mehmet Kaynar, Murat Celik |
|---|---|
| Přispěvatelé: | Selçuk Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Kaynar, Mehmet., Celik, Z. Esin., Kilic, Ozcan., Akand, Murat., Goktas, Serdar. |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Fuhrman grading system Lymphovascular invasion Urology medicine.medical_treatment 030232 urology & nephrology 03 medical and health sciences 0302 clinical medicine Renal cell carcinoma medicine.artery Ring box protein-1 medicine Humans Stage (cooking) Renal artery Vein Pathological Carcinoma Renal Cell Aged Renal cell cancer business.industry Middle Aged medicine.disease Immunohistochemistry Nephrectomy Kidney Neoplasms medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Female Neoplasm Grading business Carrier Proteins |
| Zdroj: | Urologic oncology. 38(1) |
| ISSN: | 1873-2496 |
| Popis: | WOS: 000499961100016 PubMed: 31653562 Objective: To determine the relationship between RING-box protein 1 (RBX-1) expression and renal cell carcinoma (RCC) with prognostic factors. Methods: A total of 88 patients who underwent radical/partial nephrectomy between January 2009 and January 2016 have been included in our study. The age, gender, tumor location, tumor size, and tumor-node-metastasis stage of each patient was evaluated. From the best sections in hematoxylin-eosin stained pathology preparations, tumor histological subtype, Fuhrman nuclear grade, lymphovascular invasion, renal artery/vein invasion, capsule invasion, perirenal fatty tissue invasion, and tumor grade were evaluated. Participants were divided into 2 groups according to Fuhrman grade. Fuhrman grades 1 to 2 comprised Group 1, and Fuhrman grades 3 to 4 comprised Group 2. An immunoreactivity scoring system was used to evaluate RBX-1 expression. Results: Upon examining all histological subtypes together, it was observed that RBX-1 expression was statistically higher in Group 2 compared to Group 1 (P < 0.008). Upon examining clear RCC cases, it was observed again that Group 2 had a higher RBX-1 expression than Group 1 (P < 0.009). RBX-1 expression was not associated with clinical-pathological parameters including tumor grade, lymphovascular invasion, capsule invasion, or perirenal invasion. Conclusion: RBX-1 expression is closely associated with a highly important prognostic factor in RCC-Fuhrman grade-and it shows promise as a prognostic marker. Further studies are required to reveal the importance of RBX-1 in RCC prognosis and treatment. (C) 2019 Elsevier Inc. All rights reserved. |
| Databáze: | OpenAIRE |
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