Comparison of Hematopoietic Stem Cell Transplantation Results in Patients with β-Thalassemia Major from Three Different Graft Types

Autor:	Ceyhun Bozkurt, Tunç Fışgın, Başak Adaklı Aksoy, Funda E Cipe, Selime Aydogdu, Ersin Töret, Muhammed Fatih Aydın
Přispěvatelé:	İstinye Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü, Başaklı Adaklı Aksoy / 0000-0001-8338-2101, Ceyhun Bozkurt / 0000-0001-6771-9894, Adaklı Aksoy, Başak, Bozkurt, Ceyhun, Başak Adaklı Aksoy / AAK-3627-2021, Ceyhun Bozkurt / AAL-5043-2021, Ceyhun Bozkurt / 6602784315
Rok vydání:	2021
Předmět:	Treosulfan Thalassemia medicine.medical_treatment Clinical Biochemistry Graft vs Host Disease Hematopoietic stem cell transplantation Human leukocyte antigen Non-Sibling Family Donor Pediatrics hemic and lymphatic diseases Medicine Humans In patient Family Genetics (clinical) business.industry Biochemistry (medical) beta-Thalassemia Hematopoietic Stem Cell Transplantation Hematology medicine.disease Fetal Blood surgical procedures operative Immunology business β thalassemia major Hematopoietic Stem Cell Transplantation (HSCT) medicine.drug
Zdroj:	Hemoglobin. 45(1)
ISSN:	1532-432X
Popis:	Allogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for β-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood banks have carried out diligent searches to find matched unrelated donors (MUDs) for about 70.0% of patients from 2000 onwards. The chance of finding a non-sibling fully matched family donors is higher in some ethnic groups in which consanguineous marriages are common. We have studied and compared transplant complications and outcomes in different graft types (sibling, non-sibling family and unrelated). The non-sibling matched family donor (MFD) group consisted of four mothers, three fathers, five cousins, one paternal uncle and one paternal aunt. There was no significant difference in the mean transfused CD34+ cells, engraftment, median days of neutrophil and platelet recovery were achieved (p > 0.05). The distribution of postttransplant complication did not show any significant difference between groups (p > 0.05). In univariate analysis and multivarite analyses, age, gender, Pesaro risk group (I-II vs. III) and ABO incompatibilty demonstrated a significant difference in disease free survival (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc98b350ebc023b44c534acc4f0fea0c https://pubmed.ncbi.nlm.nih.gov/33478286 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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