Synthesis and characterization of Mn(I) complexes and their larvicidal activity against Aedes aegypti, vector of dengue fever
| Autor: | Mário Antônio Navarro-Silva, Edjane R. dos Santos, Rose M. Carlos, Valéria R. S. Malta, Francisco A. Marques, Vinicius Annies, Ana Carolina Mafud, Inara de Aguiar, Maria Teresa do Prado Gambardella |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
DENGUE Stereochemistry chemistry.chemical_element Aedes aegypti Manganese 010402 general chemistry 01 natural sciences Inorganic Chemistry 03 medical and health sciences chemistry.chemical_compound Materials Chemistry Physical and Theoretical Chemistry Cholinesterase chemistry.chemical_classification biology Chemistry fungi biology.organism_classification Acetylcholinesterase Enzyme assay 0104 chemical sciences Mosquito control 030104 developmental biology Enzyme Proton NMR biology.protein |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1387-7003 |
| Popis: | This article describes the structure (X-ray), spectroscopic properties (FTIR, UV–vis, 1H NMR) and larvicidal activity of Mn(I) complexes, fac-[Mn(CO)3(phen)(L)]+, where phen = 1,10′-phenanthroline and L = 2-methyl-imidazole, 4-methyl-imidazole, and 2-phenyl-imidazole. The mode of action on the cholinesterase enzyme activity and the Cytochrome-C (P450) inhibition are also reported. The complexes were highly effective against A. aegypti larvae causing up to 90% mortality at 0.033 to 0.046 g/L concentration in 4 days, showing their great potential to control mosquito proliferation. The complexes do not interact with acetylcholinesterase enzyme from the A. aegypti mosquito, but react strongly with the P450 enzyme under light irradiation, reducing the Fe(III) to Fe(II). This is very important since P450 has implications on the insecticidal resistance of the mosquitoes. In addition, manganese is one of the most abundant metals on earth and an essential element for life; therefore, no harmful effect on humans or environment is expected with the use of these compounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect