Anti-parasite effects of cytokines in malaria
| Autor: | Kamini N. Mendis, Richard Carter, Giuseppe Del Giudice, Georges E. Grau, Nadira D. Karunaweera, T. de S. Naotunne |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
medicine.medical_treatment
Immunology Plasmodium vivax Interferon-gamma Immune system Immunity Interferon parasitic diseases medicine Immunology and Allergy Animals Humans Innate immune system biology Tumor Necrosis Factor-alpha biology.organism_classification medicine.disease Virology Malaria Cytokine Cytokines Tumor necrosis factor alpha medicine.drug |
| Zdroj: | Immunology letters. 25(1-3) |
| ISSN: | 0165-2478 |
| Popis: | Cytokines induced during natural malaria infections, e.g., at crisis of a blood infection of Plasmodium cynomolgi, and during clinical paroxysms in human Plasmodium vivax infections, mediate killing of intra-erythrocytic blood stage malaria parasites. These cytokines, TNF and IFN-gamma, require additional, yet unidentified complementary factors that are present in "crisis" and "paroxysm" serum to kill intra-erythrocytic blood stage parasites. In contrast, cytokines, (mainly IFN-gamma) are able to effect killing of intra-hepatic stages of the parasite by themselves independent of serum complementary factors, suggesting that the mechanisms of killing may be different with respect to the two parasite stages. Cytokines also appear to be critical intermediates in mechanisms of clinical disease in malaria. Serum cytokine (TNF) levels and killing effects on blood stage malaria parasites were lower in patients who were exposed to endemic P. vivax malaria who had partial clinical immunity, than in non-immune patients. Evidence suggest that individuals acquire natural immunity to the disease by avoiding the induction of high levels of cytokines and complementary factors. |
| Databáze: | OpenAIRE |
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