Demyelinating polyneuropathy and lymphoplasmacytic lymphoma coexisting in 36-year-old man: A case report
| Autor: | Sebastian Grosicki, Marta Pietrukaniec, Małgorzata Grabarczyk, Agnieszka Żak-Gołąb, Elżbieta Semik-Grabarczyk, Lesia Rozłucka, Michał Holecki |
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| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty Paraneoplastic neuropathy Autoimmunity Chronic inflammatory demyelinating polyneuropathy medicine.disease_cause Lymphoplasmacytic Lymphoma 03 medical and health sciences 0302 clinical medicine immune system diseases Polyneuropathy hemic and lymphatic diseases Case report medicine Demyelinating polyneuropathy business.industry General Medicine medicine.disease 030220 oncology & carcinogenesis Lymphoplasmacytic lymphoma 030211 gastroenterology & hepatology business |
| Zdroj: | World Journal of Clinical Cases |
| ISSN: | 2307-8960 |
| Popis: | BACKGROUND Lymphoplasmacytic lymphoma is a rare non-Hodgkin’s lymphoma, occurring mostly in the elderly. It develops slowly and leads to malignant proliferation of lymphoid line cells in the bone marrow, lymph nodes and spleen. It may also affect nerve roots and meninges; some patients develop sensorimotor polyneuropathy which may precede general symptoms of lymphoma. CASE SUMMARY We present a case of a 36-year-old man diagnosed in 2012 with chronic inflammatory demyelinating polyneuropathy (CIDP), then he was hospitalized in 2019 due to progressive symptoms of heart failure and significant weight loss over the previous four months. Based on clinical and laboratory findings a diagnosis of lymphoplasmacytic lymphoma was suspected and confirmed by bone marrow flow cytometry. There was no improvement in the results of laboratory tests and the patient's condition after immediate implementation of chemotherapy. Patient died on the fifth day of treatment. CONCLUSION While CIDP and malignant disease co-occurrence is rare, it should be suspected and investigated in patients with atypical neuropathy symptoms. |
| Databáze: | OpenAIRE |
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