Noncovalent Self-Assembled Smart Gold(III) Porphyrin Nanodrug for Synergistic Chemo-Photothermal Therapy
| Autor: | Jiliang Yan, Bingyang Shi, Wang Jinghan, Yong Zhong, Xiao Wang, Lulu Han, Jiefei Wang, Feng Bai, Pengcheng Duan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Drug
Porphyrins Photothermal Therapy media_common.quotation_subject Thioredoxin reductase Bioengineering Protonation Antineoplastic Agents 02 engineering and technology chemistry.chemical_compound General Materials Science media_common Mechanical Engineering Photothermal effect General Chemistry Hyperthermia Induced Photothermal therapy Phototherapy 021001 nanoscience & nanotechnology Condensed Matter Physics Porphyrin Combinatorial chemistry Monomer chemistry Doxorubicin Nanoparticles Self-assembly Gold 0210 nano-technology |
| Zdroj: | Nano letters. 21(8) |
| ISSN: | 1530-6992 |
| Popis: | Self-assembly is a powerful means to fabricate multifunctional smart nanotheranostics. However, the complicated preparation, toxicity of responsive carriers, and low loading efficiency of drug cargo hinder the outcome. Herein, we developed a responsive carrier-free noncovalent self-assembly strategy of a metallized Au(III) tetra-(4-pyridyl) porphine (AuTPyP) anticancer drug for the preparation of a heat/acid dual-stimulated nanodrug, and it generated a better photothermal effect than monomers under irradiation. The photothermal effect promoted the protonation of the hydrophobic pyridyl group and the following release into tumorous acidic microenvironments. With cRGD modification, the released drug induced the aggravation of intracellular reactive oxygen species (ROS) via the activity inhibition of thioredoxin reductase (TrxR) for synergistic chemo-photothermal therapy of tumors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|