Factors associated with potentially serious incidental findings and with serious final diagnoses on multi-modal imaging in the UK Biobank Imaging Study: A prospective cohort study
| Autor: | Nicholas C. Harvey, Nicola Doherty, Lorna Gibson, Steve Garratt, Naomi E. Allen, Thomas J. Littlejohns, Cathie Sudlow, Joanna M. Wardlaw, John Nolan, Caroline A. Jackson, Steffen E. Petersen, Jonathan Sellors, Edouard Mathieu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics Physiology Epidemiology Disease Multimodal Imaging Body Mass Index Diagnostic Radiology 0302 clinical medicine Risk Factors Medicine and Health Sciences Public and Occupational Health Prospective Studies Medical Personnel 030212 general & internal medicine Medical diagnosis Prospective cohort study Biological Specimen Banks 2. Zero hunger Incidental Findings Alcohol Consumption Multidisciplinary Radiology and Imaging Smoking Middle Aged Magnetic Resonance Imaging Biobank 3. Good health Professions Physiological Parameters Cohort Medicine Female Research Article Adult medicine.medical_specialty Alcohol Drinking Imaging Techniques Science Research and Analysis Methods Ethnic Epidemiology 03 medical and health sciences Diagnostic Medicine Radiologists medicine Humans Exercise Life Style Nutrition business.industry Body Weight Biology and Life Sciences Physical Activity United Kingdom Confidence interval Diet Health Care People and Places Population Groupings Health Statistics Morbidity business Body mass index 030217 neurology & neurosurgery |
| Zdroj: | Sudlow, C, Gibson, L, Nolan, J, Littlejohns, T J, Mathieu, E, Garratt, S, Doherty, N, Petersen, S E, Harvey, N C W, Sellors, J, Allen, N E, Wardlaw, J & Jackson, C 2019, ' Factors associated with potentially serious incidental findings and with serious final diagnoses on multi-modal imaging in the UK Biobank Imaging Study: a prospective cohort study ', PLoS ONE, vol. 16, no. 6, e0218267 . https://doi.org/10.1371/journal.pone.0218267 PLoS ONE PLoS ONE, Vol 14, Iss 6, p e0218267 (2019) |
| ISSN: | 1932-6203 |
| Popis: | Background Feedback of potentially serious incidental findings (PSIFs) to imaging research participants generates clinical assessment in most cases. Understanding the factors associated with increased risks of PSIFs and of serious final diagnoses may influence individuals’ decisions to participate in imaging research and will inform the design of PSIFs protocols for future research studies. We aimed to determine whether, and to what extent, socio-demographic, lifestyle, other health-related factors and PSIFs protocol are associated with detection of both a PSIF and a final diagnosis of serious disease. Methods and findings Our cohort consisted of all UK Biobank participants who underwent imaging up to December 2015 (n = 7334, median age 63, 51.9% women). Brain, cardiac and body magnetic resonance, and dual-energy x-ray absorptiometry images from the first 1000 participants were reviewed systematically by radiologists for PSIFs. Thereafter, radiographers flagged concerning images for radiologists’ review. We classified final diagnoses as serious or not using data from participant surveys and clinical correspondence from GPs up to six months following imaging (either participant or GP correspondence, or both, were available for 93% of participants with PSIFs). We used binomial logistic regression models to investigate associations between age, sex, ethnicity, socio-economic deprivation, private healthcare use, alcohol intake, diet, physical activity, smoking, body mass index and morbidity, with both PSIFs and serious final diagnoses. Systematic radiologist review generated 13 times more PSIFs than radiographer flagging (179/1000 [17.9%] versus 104/6334 [1.6%]; age- and sex-adjusted OR 13.3 [95% confidence interval (CI) 10.3–17.1] p Conclusion Risks of PSIFs and serious final diagnosis are substantially influenced by PSIFs protocol and to a lesser extent by age. As only 1/5 PSIFs represent serious disease, evidence-based PSIFs protocols are paramount to minimise over-investigation of healthy research participants and diversion of limited health services away from patients in need. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|