MRI monitoring of interstitial microwave-induced heating and thermal lesions in rabbit brain in vivo
| Autor: | Lee C. Ang, R. D. Peters, John A. Moriarty, Donald B. Plewes, Julian C. Chen, Carrie M. Purcell, Michael Bronskill, R. Scott Hinks, Walter Kucharczyk, R. Mark Henkelman |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Pathology medicine.medical_specialty Artifact (error) Materials science Phase (waves) Brain Hyperthermia Induced Rabbit brain Magnetic Resonance Imaging Signal Diathermy In vivo Thermal medicine Animals Radiology Nuclear Medicine and imaging Thermal damage Rabbits Microwaves Microwave Biomedical engineering |
| Zdroj: | Journal of Magnetic Resonance Imaging. 8:128-135 |
| ISSN: | 1522-2586 1053-1807 |
| DOI: | 10.1002/jmri.1880080125 |
| Popis: | The purpose of this experiment was to use MRI to monitor microwave heating and thermal damage of brain tissue in vivo. Interstitial microwave antennas were implanted into the cerebral hemispheres of seven anesthetized rabbits. Variable power of 30 to 100 W was applied for periods of 5 to 15 minutes and tissue temperature was monitored continuously. MR images were obtained throughout the procedure at 20-second intervals, using a spoiled gradient-echo sequence, without significant artifact. Magnitude, phase, and complex difference images all demonstrated temperature-related signal changes during heating. The findings were better visualized on the phase and complex difference images. Phase difference image analysis revealed an approximately linear relationship between phase change and temperature. Post-treatment thermal lesions measured up to 2.0 cm in size on pathologic specimens and exhibited a zonal pattern on spin-echo MR images. |
| Databáze: | OpenAIRE |
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