Equilibrium Exchange Processes of the Aqueous Tryptophan Dipeptide
Autor: | Robin M. Hochstrasser, Sayan Bagchi, Adam Kenneth Charnley, Amos B. Smith |
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Rok vydání: | 2009 |
Předmět: |
Aqueous solution
Dipeptide Spectrophotometry Infrared Stereochemistry Tryptophan Dipeptides Equilibrium exchange Article Surfaces Coatings and Films chemistry.chemical_compound Crystallography Models Chemical chemistry Amide Materials Chemistry Computer Simulation Deuterium Oxide Physical and Theoretical Chemistry Spectroscopy Conformational isomerism |
Zdroj: | The Journal of Physical Chemistry B. 113:8412-8417 |
ISSN: | 1520-5207 1520-6106 |
Popis: | The tryptophan dipeptide (NATMA) in D2O shows two conformers having distinctive acetyl end amide-I' transition frequencies. In two dimensional echo spectroscopy cross peaks between these conformer transitions are used to show they are undergoing exchange on the 1.5 ps time scale. Simulations suggest that the accessibility of the amide group to water is restricted in one of the conformations. |
Databáze: | OpenAIRE |
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