Protective effect of Crassostrea gigas extract on audiogenic seizures in magnesium deficient mice
| Autor: | Nicole Pages, H Tapiero, P Bac, S Dhalluin |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty Taurine Antioxidant Ratón medicine.medical_treatment chemistry.chemical_element Mice chemistry.chemical_compound Seizures Internal medicine Magnesium deficiency (medicine) medicine Deficient mouse Animals Pharmacology biology Magnesium General Medicine biology.organism_classification medicine.disease Ostreidae Surgery Endocrinology Acoustic Stimulation chemistry Mice Inbred DBA Food Fortified Crassostrea Prostration Magnesium Deficiency |
| Zdroj: | Biomedicine & Pharmacotherapy. 52:162-165 |
| ISSN: | 0753-3322 |
| DOI: | 10.1016/s0753-3322(98)80205-9 |
| Popis: | Summary Audiogenic seizures associated with loss of weight, prostration, piloerection, palpebral ptosis and motor deficiency were induced after sound stimulation of determined frequency and amplitude in magnesium-deficient DBA/2 mice. These symptoms were maintained when standard diet conditions (1700 ppm Mg2+) were restored. In contrast, mice were protected from audiogenic seizure in a dose related manner when Crassostrea gigas extract (JCOE) were added to the diet for 10 consecutive days. Although a rational explanation for this protective effect has not yet been determined, it is assumed that it might be due to a chelating complex formed between Mg2+ and taurine, which enhance the uptake of Mg2+. © 1998 Elsevier, Paris. |
| Databáze: | OpenAIRE |
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