Use of DNA transposons for functional genetic screens in mouse models of cancer
| Autor: | Camino Bermejo-Rodríguez, Pedro A. Perez-Mancera |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Transposable element
Genetics Biomedical Engineering Cancer Bioengineering Disease Biology medicine.disease Genome Disease Models Animal Mice chemistry.chemical_compound chemistry Mutagenesis Neoplasms DNA Transposable Elements medicine Animals Humans Identification (biology) Genetic Testing Gene DNA Biotechnology Genetic screen |
| Zdroj: | Current Opinion in Biotechnology. 35:103-110 |
| ISSN: | 0958-1669 |
| Popis: | Cancer is a very heterogeneous disease with complex genetic interactions. In recent years, the systematic sequencing of cancer genomes has provided information to design personalized therapeutic interventions. However, the complexity of cancer genomes commonly makes it difficult to identify specific genes involved in tumour development or therapeutic responsiveness. The generation of mouse models of cancer using transposon-mediated approaches has provided a powerful tool to unveil the role of key genes during cancer development. Here we will discuss how the use of forward and reverse genetic approaches mediated by DNA transposons can support the investigation of cancer pathogenesis, including the identification of cancer promoting mechanisms and potential therapeutic targets. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect