Fractional exhaled nitric oxide (FENO), lung function and airway hyperresponsiveness in naive atopic asthmatic children
| Autor: | Michele Miraglia Del Giudice, Gl Piacentini, F. Decimo, M. Pedullà, F. P. Brunese, Carlo Capristo, Capristo A |
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| Přispěvatelé: | Pedulla', Marcella, MIRAGLIA DEL GIUDICE, Michele, Brunese, F., Piacentini, G. M., Capristo, Carlo, Decimo, Fabio, Capristo, A. F. |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Adolescent Provocation test Nitric Oxide Gastroenterology Sensitivity and Specificity Severity of Illness Index Bronchial Provocation Tests Sampling Studies Pulmonary function testing Predictive Value of Tests Internal medicine medicine Immunology and Allergy Humans Child Methacholine Chloride Asthma Probability business.industry Fractional exhaled nitric oxide Hyperresponsiveness Atopic Fractional exhaled nitric oxide Hyperresponsiveness Atopic Exhalation respiratory system Immunoglobulin E medicine.disease Prognosis respiratory tract diseases Respiratory Function Tests medicine.anatomical_structure Predictive value of tests Pediatrics Perinatology and Child Health Exhaled nitric oxide Methacholine Female Bronchial Hyperreactivity business Biomarkers Respiratory tract medicine.drug |
| Popis: | Background. Measurement of fractional exhaled nitric oxide (FENO) is a noninvasive,simple, well-tolerated, and reproducible marker of airway inflammation. Asthmatic children with normal respiratory function could be affected by airway inflammation. The aim of this study was to assess the correlation between FENO and bronchial hyperesponsivenes(Bs HR) to methacholine and between FENO and lung function in atopic children with intermittent asthma. Methods. Thirty-seven children (21 male), aged 7.2-14.4 years (median: 10.9 years), suffering from mild intermittent atopic asthma with a physician-diagnosed history of wheezing and/or chest tightness were studied. None had taken anti-asthmatic therapy for at least three months before the study. No child had symptoms of respiratory tract infection in the month before the study. All subjects underwent FENO measurement, pulmonary function testing and the methacholine provocation tests. Results. The mean percentages of FEVI and FEF25-75 were 91.9+10.5 and 88.3+11.8, respectively.The mean FENO was 62.2+39.2 ppb and PC20 methacholine was 0.93 mg/ml+0.54. Significant correlations were identified between FENO and FEVI (p |
| Databáze: | OpenAIRE |
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