Twist and snai1 expression in pharyngeal squamous cell carcinoma stroma is related to cancer progression

Autor: Veli-Matti Kosma, Matti Pukkila, Hanna Tuhkanen, Reijo Sironen, Mervi Närkiö-Mäkelä, Anna Jouppila-Mättö, Ylermi Soini, Arto Mannermaa
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Adult
Male
Cancer Research
Pathology
medicine.medical_specialty
SNAI1
Stromal cell
Epithelial-Mesenchymal Transition
Kaplan-Meier Estimate
lcsh:RC254-282
Twist transcription factor
Stroma
Pharyngeal squamous cell carcinoma
Genetics
medicine
Humans
Epithelial–mesenchymal transition
Longitudinal Studies
Stromal cells
Finland
Aged
Aged
80 and over
Analysis of Variance
Chi-Square Distribution
business.industry
Twist-Related Protein 1
Cancer
TWIST
Nuclear Proteins
Pharyngeal Neoplasms
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Prognosis
Immunohistochemistry
Oncology
Carcinoma
Squamous Cell
Disease Progression
Pharyngeal Squamous Cell Carcinoma
Female
Snail Family Transcription Factors
business
Immunostaining
Research Article
Transcription Factors
Zdroj: BMC Cancer
BMC Cancer, Vol 11, Iss 1, p 350 (2011)
ISSN: 1471-2407
Popis: Background Epithelial-mesenchymal transition (EMT) is a crucial process in tumorigenesis since tumor cells attain fibroblast-like features enabling them to invade to surrounding tissue. Two transcription factors, TWIST and SNAI1, are fundamental in regulating EMT. Methods Immunohistochemistry was used to study the expression of TWIST and SNAI1 in 109 pharyngeal squamous cell carcinomas. Results Tumors with intense stromal staining of TWIST relapsed more frequently (p = 0.04). Tumors with both positive TWIST and SNAI1 immunoreactivity in the stroma were at least Stage II (p = 0.05) and located more often in hypopharynx (p = 0.035). Tumors with negative immunostaining of TWIST and SNAI1 in the stromal compartment were smaller (T1-2) (p = 0.008), less advanced (SI-II) (p = 0.031) and located more often in the oropharynx (p = 0.007). Patients with negative SNAI1 and TWIST immunostaining in tumor stroma had a better 5-year disease-specific and overall survival (p = 0.037 and p = 0.014 respectively). Conclusion TWIST and SNAI1 expression in stromal cells is associated with clinical and histopathological characteristics that indicate progressive disease. Negative expression of these EMT-promoting transcription factors predicts a better outcome.
Databáze: OpenAIRE
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