Arginase, nitrates, and nitrites in the blood plasma and erythrocytes in hypertension and after therapy with lisinopril and simvastatin
| Autor: | A. V. Suslikov, G. L. Ermakov, Lyudmila A. Tikhonova, Yu. G. Kaminskii, M. Kh. Galimova, V. D. Tsvetkov, E. A. Kosenko |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Combination therapy Lisinopril Nitric Oxide Synthase Type III Arteriosclerosis Biology Pharmacology medicine.disease General Biochemistry Genetics and Molecular Biology Nitric oxide Arginase chemistry.chemical_compound Endocrinology chemistry Simvastatin Internal medicine Blood plasma medicine General Agricultural and Biological Sciences circulatory and respiratory physiology medicine.drug |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1608-3059 1062-3590 |
| DOI: | 10.1134/s1062359011050074 |
| Popis: | Arginase activity in erythrocytes is higher in patients with arterial hypertension and atherosclerosis as compared with healthy patients. Therapy with either lisinopril alone or in combination with simvastatin for 3–6 months causes a decrease in the arginase activity to the control level. Both the monotherapy and the combination therapy increased the concentrations of N 2 − , N 3 − , and total N 2 − + N 3 − in the plasma of hypertensive patients. The N 2 − + N 3 − concentration in erythrocytes decreases in hypertensive patients but is completely restored after therapy with lisinopril alone or in combination with simvastatin. Thus, lisinopril and lisinopril plus simvastatin display a pronounced and equal normalizing effect on arginase activity in human erythrocytes, which is elevated in hypertension, as well as on the endothelial nitric oxide synthase activity, which is decreased in hypertension. |
| Databáze: | OpenAIRE |
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