Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue
| Autor: | Hiroshi Kudo, Masakiyo Sasahara, Yutaka Yata, Seiichi Morita, Toshiro Sugiyama, Yasuhiro Nakayama, Terumi Takahara, Masami Kanayama, Takeshi Oya, Derek A. Mann, Kengo Kawai |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Liver Cirrhosis
Male CCR2 Adipose tissue Blood Pressure Benzoates Eating Mice chemistry.chemical_compound Methionine hemic and lymphatic diseases Adipocyte Adipocytes Telmisartan Chemokine CCL2 Fatty liver Organ Size Choline Deficiency Liver Disease Progression Adiponectin medicine.drug medicine.medical_specialty Receptors CCR2 Drinking Intra-Abdominal Fat Biology Collagen Type I Cell Line Transforming Growth Factor beta1 Internal medicine medicine Animals RNA Messenger Triglycerides Cell Size Hepatology Macrophages medicine.disease Angiotensin II Fatty Liver Mice Inbred C57BL Disease Models Animal Oxidative Stress Endocrinology chemistry Benzimidazoles Steatohepatitis Angiotensin II Type 1 Receptor Blockers Lipoprotein |
| Zdroj: | Liver International. 29:988-996 |
| ISSN: | 1478-3231 1478-3223 |
| DOI: | 10.1111/j.1478-3231.2009.02006.x |
| Popis: | Background/Aims: Non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NASH) are the hepatic manifestation of metabolic syndrome. However, its therapeutic strategy has not been established. Recently, an angiotensin II type 1 receptor blocker, telmisartan (Tel), has received a great deal of attention as a therapeutic tool for metabolic syndrome. The aim of this study was to investigate the efficacy and mechanisms of Tel on a murine NASH model. Methods: C57BL/6 mice were fed a methionine- and choline-deficient high-fat diet (MCDHF) or a standard diet with/without the administration of Tel (10 mg/kg/day) for 8 weeks. Results: MCDHF feeding induced marked steatohepatitis with macrophage infiltration. Tel attenuated liver steatosis with decreased hepatic triglycerides (P |
| Databáze: | OpenAIRE |
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