Preparation of procoligenoids from Escherichia coli heat-labile enterotoxins
| Autor: | L C Rieke, Richard A. Finkelstein, C V Sciortino, M F Burks, M Boesman-Finkelstein |
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| Jazyk: | angličtina |
| Rok vydání: | 1984 |
| Předmět: |
Hot Temperature
Chemical Phenomena Polymers Swine Immunology Bacterial Toxins Enterotoxin Biology medicine.disease_cause Microbiology Procholeragenoid Enterotoxins Antigen medicine Escherichia coli Heat-stable enterotoxin Animals Humans Antigens Bacterial Choleragenoid Escherichia coli Proteins Biological activity Toxoids Molecular Weight Chemistry Infectious Diseases Toxicity Parasitology Research Article |
| Popis: | Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further heating results in the release of B-subunit oligomers, coligenoids, analogous to choleragenoid. Further studies are needed to determine whether, like procholeragenoid, the procoligenoids are superior antigens in stimulating gut immunity after parenteral administration. |
| Databáze: | OpenAIRE |
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