Comparison of thrombocytopenia between patients with non‐alcoholic fatty liver disease and those with hepatitis C virus‐related chronic liver disease

Autor: Naohiko Kinoshita, Toshihide Shima, Kei Terasaki, Hirohisa Oya, Takayuki Katayama, Junko Matsumoto, Yasuhide Mitsumoto, Masayuki Mizuno, Chiemi Mizuno, Rina Hirohashi, Kyoko Sakai, Takeshi Okanoue
Rok vydání: 2022
Předmět:
Zdroj: Hepatology Research. 52:677-686
ISSN: 1872-034X
1386-6346
DOI: 10.1111/hepr.13791
Popis: Thrombocytopenia is widely recognized as a simple surrogate marker of liver fibrosis in non-alcoholic fatty liver disease (NAFLD). Thrombocytopenia of NAFLD has not been compared with that of hepatitis C virus-related chronic liver disease (CLD-C). Here, we examined whether there is any difference in the platelet counts between patients with NAFLD and CLD-C and investigated the underlying mechanisms.A total of 760 biopsy-confirmed NAFLD and 1171 CLD-C patients were enrolled. After stratification according to the liver fibrosis stage, platelet counts between NAFLD and CLD-C patients were compared. The platelet count, spleen size, serum albumin level, serum thrombopoietin level, and immature platelet fraction (IPF) value were also compared after covariate adjustment using propensity score (PS) matching.The median platelet counts (×10NAFLD patients had a significantly higher platelet count than CLD-C patients following stratification according to the liver fibrosis stage. The milder hypersplenism and higher platelet production in NAFLD than CLD-C may have contributed to this difference.
Databáze: OpenAIRE
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