Ph1-positive and Ph1-negative abnormal cell lines in a child with lymphoblastic lymphoma
| Autor: | Takaaki Shikano, Norio Niikawa, Takeo Takeda, Yasuhiko Kaneko, Tatsuto Tonooka, Masahiro Kikuchi, Yorikazu Ishikawa |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Pathology medicine.medical_specialty T-Lymphocytes Chromosomal translocation Abnormal cell Translocation Genetic Bone Marrow Chromosomes Human 21-22 and Y medicine Humans Child Mosaicism business.industry Lymphoma Non-Hodgkin Lymphoblast Lymphoblastic lymphoma Chromosome Hematology medicine.disease Peripheral blood Lymphoma medicine.anatomical_structure Karyotyping Bone marrow business |
| Zdroj: | British Journal of Haematology. 58:459-464 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1984.tb03992.x |
| Popis: | Summary. A 7-year-old Japanese boy with Ph1-positive-lymphoblastic lymphoma is described. The diagnosis was based on biopsied tonsils which were enlarged at the time of admission. On the eighth day after admission an enlarged mediastimal mass was detected on a chest X-ray film. The lymphoblasts which appeared in the peripheral blood and bone marrow proved to be T-cells. Chromosome studies on the bone marrow cells revealed two abnormal cell lines; one had a 7; 11 translocation and the other a 7;11 translocation and a 9;22 translocation, forming the Ph1-chromosome. The latter line with the Ph1 chromosome was considered to have been derived from the former line without the Ph1. Our findings show that the Prochromosome may be a secondary change in the course of karyotypic evolution. |
| Databáze: | OpenAIRE |
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