Predictive Factors for Oral Immune Modulation in Cow Milk Allergy

Autor:	Ioana Adriana Muntean, Ioana Corina Bocsan, Lena Katharina Wiest, Irena Pintea, Carmen Teodora Dobrican, Emanuela Duca, Corina Ureche, Anca Dana Buzoianu, Diana Deleanu
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Nutrition and Dietetics Nutrition. Foods and food supply oral tolerance Caseins food and beverages cow milk allergy oral immunotherapy Lactoglobulins casein Milk Immune Tolerance Animals Humans Cattle Female TX341-641 Milk Hypersensitivity Food Science
Zdroj:	Nutrients, Vol 14, Iss 494, p 494 (2022) Nutrients; Volume 14; Issue 3; Pages: 494
ISSN:	2072-6643
Popis:	Aim: The present study analyzed clinical and biological factors that might predict achievement of tolerance in patients with IgE-mediated cow milk allergy (CMA). Method: Seventy patients with IgE-mediated CMA (44.24 ± 24.16 months) were included in the study. The patients were evaluated clinically through skin prick test and sIgE to whole milk, casein, beta-lactoglobulin and alpha-lactalbumin. An eviction diet of 6 months was established, followed by oral food challenge test (OFC) and oral immunotherapy (OIT) with baked milk for 6 months. The tolerance was assessed after 2 years follow up. Results: Thirty percent of patients presented anaphylaxis of different degrees of severity as first manifestation of CMA. Sixty-two patients followed OIT or an accelerated reintroduction of milk. Ten patients (14.28%) did not obtain tolerance to milk within 2 years. A larger wheal in SPT and higher sIgE to milk, casein and betalactoglobulin were noted in patients with positive OFC. A basal level of
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc82daa78ddfb1f1bffe727d585194f6 https://www.mdpi.com/2072-6643/14/3/494 Zobrazit plný text záznamu