Safety, tolerability, and pharmacokinetics of weight-based IV loading dose of lacosamide in the ICU
| Autor: | Vivek Sabharwal, R. Eugene Ramsay, Anil K. Chimakurthy, Uma Menon |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Lacosamide
Status epilepticus Loading dose law.invention 03 medical and health sciences Behavioral Neuroscience Epilepsy 0302 clinical medicine Pharmacokinetics law Acetamides medicine Humans 030212 general & internal medicine Retrospective Studies Volume of distribution business.industry Body Weight medicine.disease Intensive care unit Intensive Care Units Blood pressure Treatment Outcome Neurology Anesthesia Anticonvulsants Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Epilepsybehavior : EB. 114 |
| ISSN: | 1525-5069 |
| Popis: | Among the newer antiseizure medications, lacosamide (LCM) has been increasingly used for acute seizures and status epilepticus in intensive care unit (ICU). We reviewed retrospectively weight-based dosing of IV LCM in patients admitted to ICU with acute seizures and status epilepticus. We have analyzed 354/382 patient treated with IV LCM in ICU during the years 2013–2016. Data collected were age, total body weight, body mass index (BMI), loading dose, post-IV infusion LCM blood level, duration of infusion, blood pressure, heart rate, oxygen saturation, mean arterial pressures, and documented initiation of pressor agents during or within in 30 min of infusion. Larger doses > 8 mg/kg of IV LCM that can be safely administered in ICU patients produce effective plasma levels of 15–20 μg/ml with relatively constant volume of distribution. |
| Databáze: | OpenAIRE |
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