Expression of oncofoetal marker carcinoembryonic antigen in oral cancers in South India—a pilot study
| Autor: | R. M. Lalitha, MK Bhargava, SB Pai, Randal N. Johnston, S.V. Kumaraswamy, N. Lalitha, RB Pai |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Pathology Tobacco Smokeless Population India Pilot Projects Buccal mucosa Carcinoembryonic antigen Internal medicine medicine Humans education neoplasms Aged Aged 80 and over Mouth neoplasm education.field_of_study biology business.industry Diagnostic marker Middle Aged Carcinoembryonic Antigen Staining stomatognathic diseases Otorhinolaryngology Epidermoid carcinoma Carcinoma Squamous Cell biology.protein Oral Cancers Female Mouth Neoplasms Surgery Oral Surgery business |
| Zdroj: | International Journal of Oral and Maxillofacial Surgery. 35:746-749 |
| ISSN: | 0901-5027 |
| DOI: | 10.1016/j.ijom.2006.02.012 |
| Popis: | Expression of the oncofoetal glycoprotein, carcinoembryonic antigen (CEA), has been observed in a number of malignancies and is also being pursued as a target for anti-cancer therapy. This study explored the status of this biochemical entity in the oral squamous cell carcinoma (SCC) in South India caused by extensive chewing habits. Squamous cell carcinoma in the study belonged to grade I and grade II. Tumour staging of the patients recruited in the study ranged from T2N1M0 to T4N3M0. Of the grade II cases studied, 88% (7 out of 8) showed expression of CEA. The 2 cases of grade I SCC of buccal mucosa also showed positive anti-CEA staining. If the results from this pilot study can be validated with a larger sample size, a role can be attributed to this tumour marker in oral neoplasia, thereby opening up avenues for using CEA as an additional diagnostic marker in oral SCC in this population and as a possible target for anti-cancer therapy. |
| Databáze: | OpenAIRE |
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